Chemicals & Small Molecules

ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.

TRIM24/BRPF1-IN-2 (compound 20l) is an effective dual inhibitor of TRIM24/BRPF1 with IC50 values of 0.98 μM for TRIM24 and 1.16 μM for BRPF1, exhibiting strong binding affinity to the bromodomains of TRIM24/BRPF1, making it a valuable tool for prostate cancer research [1].

S-Allylmercaptocysteine HCl is an organosulfur compound isolated from aged garlic with anti-inflammatory, antioxidant, anticancer, and antitumor activities.S-Allylmercaptocysteine HCl inhibits inflammation in COPD and targets Nrf2 in osteoarthritis therapy through the NOX4/NF-kappaB pathway. Targeting Nrf2.

UDP-xylose disodium is a nature product that could be isolated from Cryptococcus laurentii (N RRL Y-1401). UDP-xylose disodium is a metabolite in the nucleotide sugar metabolism [1] .

Crocin IV (Dicrocin), a crocetin glycoside from the carotenoid pigments, exhibits significant antioxidant activity [1].

Invertase is a major enzyme present in plants and microorganisms , is often used in biochemical studies. Invertase catalyzes the hydrolysis of the disaccharide sucrose into glucose and fructose [1] .

Abrilumab, a fully human monoclonal antibody, targets the α4β7 integrin heterodimer, selectively binding to it. This specificity makes it a potential research tool for investigating inflammatory bowel disease (IBD) [1].

Tebentafusp (IMCgp100) is a bispecific fusion protein targeting the gp100 peptide-HLA-A*02:01 complex, a melanoma-associated antigen, by directing T cells toward melanoma cells expressing gp100 through a high-affinity T-cell receptor (TCR) binding domain coupled with an anti-CD3 domain, promoting T-cell engagement, inflammatory cytokine production, and cytolytic protein release, leading to direct tumor cell lysis [1] [2].

Sotrovimab (VIR 7831), a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), effectively neutralizes SARS-CoV-2, SARS-CoV-1, and various other sarbecoviruses. Developed from S309, it possesses a prolonged half-life and excellent bioavailability within the respiratory mucosa. Its mechanism potentially facilitates immune-mediated viral elimination, thereby averting the advancement of Covid-19 during the disease's early stages [1][2].