Chemicals & Small Molecules

Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].

β-Patchoulene, a tricyclic sesquiterpene extracted from Pogostemon cablin (patchouli oil), has potential therapeutic applications in the treatment of inflammatory diseases [1].

Zigakibart (BION-1301) is a humanized monoclonal antibody of the IgG4-kappa subtype, targeting TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256), and exhibits anti-inflammatory activity [1].

Thioacetamide-S-oxide, a metabolite of Thiocetamide, functions as a δ-aminolevulinic acid (ALA) synthetase inhibitor [1].

Pritumumab, a natural human IgG1kappa monoclonal antibody (mAb), was first isolated from the regional draining lymph node of a cervical carcinoma patient. It specifically recognizes cell-surface-expressed vimentin on malignant tumors and has applications in glioblastoma research [1] [2].

Lodelcizumab, a monoclonal antibody, is utilized in the study of hypercholesterolemia [1].

Compound 5e, a GPR34 receptor antagonist, exhibits selective inhibition of lysophosphatidylserine-induced ERK1/2 phosphorylation in a dose-dependent manner, demonstrating an IC50 value of 0.680 μM without significant cytotoxicity. Additionally, it displays antisensory activity in a mouse neuropathic pain model [1].

ATTO 425 is an uncharged fluorescent dye [1].

Neladalkib (NVL-655) is a selective and brain-permeable ALK inhibitor with antitumor activity that inhibits a variety of ALK-mutant oncoproteins, and may be useful in the study of non-small cell cancers.