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    Results for Chemicals ( 21791 )

      • PROTAC CBP/P300 Degrader-1

        Ref: T40143
        Sizes: 5 mg, 10 mg

        PROTAC CBP/P300 Degrader-1 (Legacy Tebubio ref. 282T40143). PROTAC CBP/P300 Degrader-1 is an effective compound that potently degrades CBP/P300, significantly reducing cell viability in various cancer cell lines.

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      • PROTAC IRAK3 degrade-1

        Ref: T40334
        Sizes: 5 mg

        PROTAC IRAK3 degrade-1 (Legacy Tebubio ref. 282T40334). PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).

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      • FKBP12 PROTAC dTAG-13

        Ref: T11291
        Sizes: 5 mg

        FKBP12 PROTAC dTAG-13 (Legacy Tebubio ref. 282T11291). FKBP12 PROTAC dTAG-13 (dTAG-13) is a heterobifunctional degrader that targets FKBP12F36V with FKBP12F36V expressed in-frame with a protein of interest, and selectively degrades the BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to the E3 ubiquitin ligase CRBN.

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      • FKBP12 PROTAC dTAG-7

        Ref: T11292
        Sizes: 5 mg

        FKBP12 PROTAC dTAG-7 (Legacy Tebubio ref. 282T11292). FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by linking BET bromodomains to the E3 ubiquitin ligase CRBN. It also functions as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.

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      • PROTAC(H-PGDS)-7

        Ref: T41267
        Sizes: 1 mg, 500 μg

        PROTAC(H-PGDS)-7 (Legacy Tebubio ref. 282T41267). PROTAC(H-PGDS)-7 is a selective and potent small molecule hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degradation agent that exhibits degradation activity in KU812 cells with a DC50 of 17.3 pM. It effectively inhibits prostaglandin D2 (PGD2) and is a candidate compound for the treatment of DMD and other H-PGDS-related diseases.

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      • Gefitinib-based PROTAC 3

        Ref: T5437
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg

        Gefitinib-based PROTAC 3 (Legacy Tebubio ref. 282T5437). Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].

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      • PROTAC CDK9 Degrader-1

        Ref: T5438
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)

        PROTAC CDK9 Degrader-1 (Legacy Tebubio ref. 282T5438). PROTAC CDK9 Degrader-1 is a selective PROTAC CDK9 degrader composed of a cereblon ligand and a CDK9 ligand.

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      • PROTAC ERRα ligand 2

        Ref: T5835
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)

        PROTAC ERRα ligand 2 (Legacy Tebubio ref. 282T5835). PROTAC ERRα ligand 2 is an inverse agonist for the estrogen-related receptor α (ERRα) with an IC50 of 5.67 nM.

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      • PROTAC CDK12/13 Degrader-1

        Ref: T64284
        Sizes: 25 mg, 100 mg, 50 mg

        PROTAC CDK12/13 Degrader-1 (Legacy Tebubio ref. 282T64284). PROTAC CDK12/13 Degrader-1 (7f) is a potent and selective dual degrader of the cell cycle protein-dependent kinases CDK12 (DC50: 2.2 nM) and CDK13 (DC50: 2.1 nM), used in the context of breast cancer.

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