Results for Click Chemistry ( 905 )
Boc-Val-Cit-PAB-PNB is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell.PNP can be substituted by amine bearing molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Mal-PEG8-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a maleimide PEG8 moiety, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Mal is reactive with thiol group of antibody. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Mal-amido-PEG8-val-gly-PAB-OH is a reagent featuring a maleimide, a hydrophilic PEG spacer, a Val-Gly dipeptide, and a PAB group with its free benzylic alcohol. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads, while the maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Gly dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.