Results for Click Chemistry ( 905 )
SGC-CBP30 is a potent CBP/p300 bromodomain (BRD) inhibitor. SGC-CBP30 shows Kd values are 21 and 32 nM for CBP and p300 BRDs respectively. SGC-CBP30 also exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. SGC-CBP30 accelerates FRAP recovery in cells at a concentration of 1 μM. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
XMD 8-92 is shown to be an extremely selective ERK5 (BMK 1) inhibitor that presents selectivity over 402 diverse kinases. XMD 8-92 shows Kd values of 80 and 190 nM for ERK5 (BMK1) and BRD4 inhibition, respectively. XMD 8-92 also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). XMD 8-92 has been shown to block growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. XMD 8-92 reduces BMK1-dependent transactivating activity of MEF2C. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Potent MDM2 inhibitor with an IC50 = 6 nM in binding assay and 30 nM in cancer cell proliferation assay. Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Silane-PEG-Azide, MW 1,000 is a PEG linker containing azido and triethoxysilane moieties. The azide can be used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The triethoxysilane moiety is used for surface modification. The hydrophilic PEG linkers increase the water solubility properties of compounds in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Silane-PEG-Azide, MW 2,000 is a PEGylation reagent with azido and triethoxysilane moieties. The azide can be used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The triethoxysilane moiety is used for surface modification. The hydrophilic PEG linkers increase the water solubility properties of compounds in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Silane-PEG-Azide, MW 3,400 is a bifunctional PEG polymer. The azide can be used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The triethoxysilane moiety is used for surface modification. The hydrophilic PEG linkers increase the water solubility properties of compounds in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Silane-PEG-Azide, MW 5,000 has azido and triethoxysilane moieties. The azide can be used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The triethoxysilane moiety is used for surface modification. The hydrophilic PEG linkers increase the water solubility properties of compounds in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Silane-PEG-Azide, MW 10,000 is a PEG linker containing azido and triethoxysilane moieties. The azide can be used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The triethoxysilane moiety is used for surface modification. The hydrophilic PEG linkers increase the water solubility properties of compounds in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.