10-Hydroxycamptothecin (HCPT) is a pyranoindolizinoquinoline that has been shown to have a strong antitumor activity. 10-Hydroxycamptothecin has been used in antibody-drug conjugate (ADC) research.
Irinotecan HCl is an anti-tumor drug that is often employed in chemotherapy and ADC drug development. Its active metabolite, SN38, acts as a DNA topoisomerase I inhibitor, halting DNA synthesis and causing single-strand breaks in DNA.
Topotecan is a chemotherapeutic agent medication and acts as a topoisomerase inhibitor. Topotecan is asynthetic, water-soluble analog of camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types.