Click Chemistry

Gimatecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Eribulin Mesylate is a synthetic taxane that binds to and prevents the function of topoisomerase I, which is essential for DNA replication, transcription, and cell division. Eribulin Mesylate can inhibit experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Eribulin is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin suppressed centromere dynamics at concentrations that arrest mitosis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PNU159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes that is more potent and well tolerated ADC cytotoxin than doxorubicin. PNU159682 is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity and shows over 3,000-fold cytotoxic than MMDX and doxorubicin. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Dolastatin 10 is a potent antimitotic peptide that inhibits tubulin polymerization. Dolastatin 10 consists of four amino acids, in order from the amino terminus: dolavaline, valine, dolaisoleucine, and dolaproine. Monomethylauristatin E (MMAE) is a synthetic dolastatin 10 derivative with pronounced activity and toxicity. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative. Soblidotin inhibits tubulin polymerization, resulting in cell cycle arrest and induction of apoptosis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc is a hexacyclic chemical compound analogous to camptothecin with a glycine linked to a terminal Fmoc group. Exatecan-2-(aminomethoxy)acetamide-Gly can be used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Exatecan-2-(aminomethoxy)acetamide-Gly is a hexacyclic chemical compound analogous to camptothecin with a terminal acetamide-gly group. Exatecan-2-(aminomethoxy)acetamide-Gly can be used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-Fmoc is a hexacyclic chemical compound analogous to camptothecin with a triplet amino acid chain linked to a terminal Fmoc group. Exatecan-2-(aminomethoxy)acetamide-Gly can be used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination. The amino acid linker is a cleavable linker that may be useful for drug delivery. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.