Results for Click Chemistry ( 905 )
- Ref: BP-29366Sizes: 5 MG, 25 MG, 50 MG, 10 MG
Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly is a hexacyclic chemical compound analogous to camptothecin with a terminal four amino acid group. Exatecan-2-(aminomethoxy)acetamide-Gly can be used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination. The amino acid linker is a cleavable linker that may be useful for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide is a protease cleavable linker with a carboxylic acid group on the N terminus and is used for the antibody-drug conjugate (ADC). The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
- Ref: BP-29527Sizes: 1 G, 100 MG, 500 MG, 250 MG
Fmoc-Gly-Gly-L-Phe-N-[(Cbz-estermethoxy)methyl]Glycinamide is a cleavable ADC linker with an Fmoc group and a benzyl (Cbz) protecting group. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The benzyl protecting group can be removed via hydrogenolysis to form a free amine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
- Ref: BP-29528Sizes: 1 G, 100 MG, 500 MG, 250 MG
Fmoc-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide is a cleavable ADC linker with an Fmoc group and a terminal carboxylic acid group. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Fmoc-Gly-Gly-L-Phe is a cleavable ADC linker with an Fmoc group and a terminal carboxylic acid group. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Mal-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide is a cleavable ADC linker with a maleimide group and a terminal carboxylic acid group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
Deruxtecan, a topoisomerase I inhibitor, is an exatecan derivative with a cleavable pepetide linker and a maleimide group. The maleimide group in Deruxtecan can react with antibody to form antibody-drug conguates (ADC) such as Trastuzumab deruxtecan, which is a HER2-targeting antibody–drug conjugate. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.