Click Chemistry

Val-Cit-PAB-MMAF is a cleavable ADC linker bound to Monomethyl auristatin F (MMAF). MMAF is an antitubulin agent that inhibits cell division by blocking the polymerization of tubulin. . The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

endo-BCN-PEG4-Val-Cit-PAB-MMAF is a precursor of antibody drug conjugate and is a click chemistry reagent. The BCN group enable copper free click chemitry with azide-tagged molecules. It contains a a protease-sensitive Val-Cit dipeptide, and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Reagent grade, for research use only.

Acid-C18-D-Glu-PEG2-amide-PEG2-amine is a branched PEG linker with a terminal amine group and two terminal carboxylic acid groups. The amino(NH2) is reactive withactivated NHS esters or carboxylic acid in the presence of EDC or HATU. The terminal carboxylic acid gourps can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only.

2-(3-Chloropropyl)-1H-isoindole-1,3(2H)-dione is a tranquilizing drug that belongs to the class of indazoles. Reagent grade, for research use only.

2-(5-Azidopentyl)isoindoline-1,3-dione is a phthalimide with a terminal azide group connected by a 5-carbon linker. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research use only.

2-(6-Azidohexyl)isoindoline-1,3-dione is a phthalimide with a terminal azide group connected by a 6-carbon linker. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research use only.

2-(7-Octyn-1-yl)-1H-isoindole-1,3-dione is a phthalimide with a terminal propargyl group connected by a 6-carbon linker. The alkyne can participate in copper-catalyzed Click Chemistry. Reagent grade, for research use only.

4-Iodobutyl benzoate is structurally related to bicyclic heterocycles such as indole and indoline. 4-Iodobutyl benzoate is a metabolite of the drug amide and is used in the treatment of inflammatory bowel disease, degenerative diseases, and bowel disease. 4-Iodobutyl benzoate works by inhibiting proteolytic enzymes through binding to their active sites. 4-Iodobutyl benzoate has been shown to inhibit the structural integrity of bacterial cells in culture by binding to calcium carbonate. 4-Iodobutyl benzoate also binds to the enzyme inhibitors that are produced by bacteria, causing them to lose their activity. This allows other drugs that would otherwise be ineffective against these bacteria because they do not reach their targets, such as alkylthio group antibiotics, to work more effectively. Reagent grade, for research use only.

5-(Biotinamido)butyllazide is a biotinylation reagent for labeling. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. Reagent grade, for research use only.