Results for Click Chemistry ( 905 )
TCO-PEG4-Val-Cit is a cleavable ADC linker featuring a TCO group, a hydrophilic PEG spacer, and a Val-Cit dipeptide. TCO is a click chemistry handle which readily reacts with tetrazine groups on a target molecule while Val-Cit dipeptides are cleaved by cytoplasmic peptidases to enable rapid and efficient drug delivery.
Bis-sulfone-PEG4-azide is a reagent featuring two sulfone groups and an azide group. The azide is a click chemistry handle which readily reacts with terminal alkynes or strained cyclooctynes to form triazole links with a target molecule. The sulfone group is a covalent ligand which is used to bind thiols via a Michael addition, and this can be employed to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time.
MC-Val-Cit-PAB-Gly is a cleavable ADC linker featuring a maleimide, a valine-citrulline (Val-Cit) dipeptide, and a para-aminobenzyl (PAB) spacer ligated to a glycine residue. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the glycine features a carboxylic acid which is free to link with amines to form amide bonds. Dipeptide cleavage by proteases triggers the PAB to efficiently release the drug payload via an elimination mechanism.
- Ref: BP-40627
MC-Val-Cit-PAB-Gly-NHS ester is a cleavable ADC linker featuring a maleimide, a valine-citrulline (Val-Cit) dipeptide, and a para-aminobenzyl (PAB) spacer ligated to a glycine-NHS residue. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the glycine features an NHS ester which is highly reactive towards amines. Dipeptide cleavage by proteases triggers the PAB to efficiently release the drug payload via an elimination mechanism.
BP Fluor 488 is a fluorescent dye. BP Fluor 488 is a fluorophore pH-insensitive over a broad pH range (from 4 to 10). It has an absorption maximum at 495 nm and an emission maximum at 519 nm in the green spectrum region. The dye is hydrophilic and can be used to introduce the fluorescent label into various molecules, including proteins and antibodies. Conjugates of molecules with BP Fluor 488 have high brightness and photostability and are commonly used in flow cytometry and microscopy. This allows the detection of biological objects with high sensitivity at a longer imaging time. BP Fluor 488 Propyl azide interacts with alkynyl derivatives of biomolecules in Click Chemistry reactions either in the presence of copper (I) catalyst (with terminal alkynes) or without catalyst (with cyclooctynes), leading to the formation of stable adducts.