Lipids & Polymers

Pomalidomide 4'-PEG5-amine (Legacy Tebubio ref. 282T83953). Pomalidomide 4'-PEG5-amine, a cereblon ligand designed for PROTAC research and development, features an integrated E3 ligase ligand and a PEG5 linker ending in an amine for easy conjugation to target protein ligands. It is among a series of functionalized tool molecules specifically crafted for PROTAC R&D.

tri-GalNAc-PEG3-Azide (Legacy Tebubio ref. 282T83964). Tri-GalNAc-PEG3-Azide is a specialized compound designed for lysosomal targeting chimera (LYTAC) research, featuring three asialoglycoprotein receptor (ASGPR) ligands linked by a PEG3 spacer and an azide group for easy conjugation. This compound facilitates efficient internalization into hepatocytes through ASGPR-mediated endocytosis, making it a strategic tool for delivering RNA, Cas9 complexes, or other cargo specifically to liver cells. Additionally, it can be utilized to create LYTACs or to be marked with a dye for tissue imaging applications.

DSPE-PEG5000-Mal ammonium (Legacy Tebubio ref. 282T84748). DSPE-PEG-Maleimide, a compound comprised of DSPE phospholipid and maleimide, is utilized for preparing nanostructured lipid carriers, enhancing both blood circulation time and stability of encapsulated agents [1] [2]. The variant DSPE-PEG5000-Mal includes PEG5000, further contributing to its utility in drug delivery systems.

Pomalidomide 4'-PEG5-azide (Legacy Tebubio ref. 282T84902). Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].

DMG-PEG 2000 (Legacy Tebubio ref. 282T9098). DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

Desoxypeganine (Legacy Tebubio ref. 282TC0022). Desoxypeganine (Deoxypeganine) is an inhibitor of cholinesterase. It acting preferentially on butyrylcholinesterase, and as a selective inhibitor of monoamine oxidase A but not monoamine oxidase B.Desoxypeganine is being developed for its potential utility in the pharmacological treatment of alcohol abuse to reduce craving and depression in alcohol abusers, and might also be useful as a smoking cessation aid.

1,1,1-Trifluoroethyl-PEG2-azide (Legacy Tebubio ref. 282T13984). 1,1,1-Trifluoroethyl-PEG2-azide is a polyethylene glycol-based azide linker compound used in synthesizing proteolysis-targeting chimeras (PROTACs)[1].

1,1,1-Trifluoroethyl-PEG4-Tos (Legacy Tebubio ref. 282T13989). 1,1,1-Trifluoroethyl-PEG4-Tos is a polyethylene glycol (PEG) derived linker molecule useful in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

1-Isothiocyanato-PEG4-alcohol (Legacy Tebubio ref. 282T13994). 1-Isothiocyanato-PEG4-alcohol, a polyethylene glycol (PEG)-derived linker compound, is suitable for incorporation into Proteolysis Targeting Chimeras (PROTACs).