Lipids & Polymers

Carboxy-Amido-PEG4-Amine is a PEG reagent containing an amino (NH2) and a terminal carboxylic acid group. The hydrophilic PEG unit increases hydrophilicity. NH2 amine group is reactive with carboxylic acids in the presence of coupling reagent such as EDC, or directly with NHS esters, to form a stable amide bond. Reagent grade, for research purpose.

20-(Bromoacetamido-PEG4-ethylcarbamoyl)heptadecanoic acid is a PEG linker containing Bromoacetamido and carboxylic acid groups. The bromo is a good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. Reagent grade, for research purpose.

20-(Bromoacetamido-PEG5-ethylcarbamoyl)heptadecanoic acid is a PEG linker containing Bromoacetamido and carboxylic acid groups. The bromo is a good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. Reagent grade, for research purpose.

N-(t-butyl ester-PEG6)-N-bis(PEG6-azide) is a 3-arm PEG reagent with a t-butyl ester group and two azide groups. The t-butyl ester group can be deprotected under acidic conditions. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Reagent grade, for research purpose.

DBCO-PEG-amine, MW 5,000 is a polyPEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research use only.

Palmityl-C6 amino phosphoramidite is a saturated fatty acid with a 16-carbon tail and a terminal propargyl group on the phosphoramidite head. Reagent grade, for research purpose.

HO-PEG-amine HCl salt, MW 2,000 is an HCl salt of a polyPEG linker with terminal amine and hydroxy groups. The compound reacts with an active NHS or PFP ester to form a stable amide linkage. The hydroxyl group can be deprotonated readily for chemical modification. Reagent grade, for research purpose.

(2,2-dimethyl-1,3-dioxan-5-yl)methyl 6-bromohexanoate is a small molecule with an acetonide protection group and a terminal bromine. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions. Acetonide protection can be removed by hydrolysis of the ketal using a dilute aqueous acid. Reagent grade, for research purpose.

3-Arm PEG5-Azide is a PEG linker containing three terminal azide groups. The azide groups enables PEGylation via Click Chemistry. Reagent grade, for research purpose.