Lipids & Polymers

Hydroxy-PEG5-acid (Legacy Tebubio ref. 282T39483). Hydroxy-PEG5-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Ethyl acetate-PEG1 (Legacy Tebubio ref. 282T39505). Ethyl acetate-PEG1 is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system [within cells].

Bis-PEG4-t-butyl ester (Legacy Tebubio ref. 282T39532). Bis-PEG4-t-butyl ester, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by connecting two essential ligands, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

FmocNH-PEG4-t-butyl ester (Legacy Tebubio ref. 282T39619). FmocNH-PEG4-t-butyl ester is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the selective degradation of proteins through the ubiquitin-proteasome system within cells.

Benzyl-PEG12-alcohol (Legacy Tebubio ref. 282T39689). Benzyl-PEG12-alcohol is a PEG-based linker for PROTACs, connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Pomalidomide 4'-PEG3-azide (Legacy Tebubio ref. 282T39806). Pomalidomide 4'-PEG3-azide is a chemically synthesized E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound is utilized in the synthesis of iRucaparib-TP3 (Compound 3), an effective PARP1 degrader developed through the PROTAC strategy and derived from Rucaparib.

Pomalidomide-amino-PEG4-NH2 hydrochloride (Legacy Tebubio ref. 282T39867). Pomalidomide-amino-PEG4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, incorporates the cereblon ligand derived from Pomalidomide, along with a linker commonly employed in PROTAC technology.

Pomalidomide-PEG6-NH2 hydrochloride (Legacy Tebubio ref. 282T39875). Pomalidomide-PEG6-NH2 hydrochloride is a compound resulting from the synthesis of an E3 ligase ligand-linker conjugate, combining the cereblon ligand derived from Pomalidomide with a 6-unit PEG linker, specifically designed for application in PROTAC technology.

Thalidomide-Piperazine-PEG3-NH2 (Legacy Tebubio ref. 282T39895). Thalidomide-Piperazine-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that combines a Thalidomide-based cereblon ligand with a linker commonly used in [PROTAC] technology, functioning as an E3 ligase recruiter.