Intelliscreen™ DNA Damage Inducers Mini-Library - 1 library

Activity: Comprises 25 compounds that induce DNA damage via different mechanisms . Function/Pharmacology: DNA damage-inducing agents have been a cornerstone of cancer treatment for decades. DNA damage of cancer cells can lead to inhibition of cellular proliferation and induction of cell death. The IntelliscreenTM DNA Damage Inducers mini-library contains classes of agents including alkylating/platinum-based reagents that directly interact with DNA, antimetabolites that interfere with DNA replication and repair, topoisomerase inhibitors, and antitumor antibiotics which function through a variety of mechanisms including intercalation, alkylation, and ROS production. Chemical Name: null