Intelliscreen™ Polycomb Repressive Complex Inhibitors Mini-L - 1 library

Activity: Comprises 6 inhibitors of the polycomb-group proteins . Function/Pharmacology: The polycomb-group proteins consist of two classes: Polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2). PRC1 acts as a histone methyltransferase primarily methylating H3K27me3 while PRC2 is a histone ubiquitin ligase acting on histone H2A. Both have important roles in epigenetic gene regulation and are implicated in various disease states because of their role in cellular proliferation-differentiation balance, metabolism, and the immune response. Chemical Name: null