Chemicals & Small Molecules

Tankyrase Inhibitor 22 (TNKSi22) is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1 nM.

Tankyrase Inhibitor 49 (TNKSi49) is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1 nM.

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor . Tubacin does not inhibit HDAC6 histone deacetylase activity; instead, tubacin is specific for the tubulin deacetylase activity of HDAC6. It reversibly inhibits α-tubulin deacetylation in mammalian cells and increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity and calpain activity. Aclarubicin acts by forming a stable complex with DNA. It was originally identified as an antitumor agent. Cell permeable.

An irreversible inhibitor of p97/vasolin (IC50=1.7 µM) identified in a cell-based protein degradation assay. Cell permeable.

Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC50 = 0.09 µM). It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.

Inhibits the p53-MDM2 interaction (20 µM). Inhibits U2Os cell growth (EC50=10 µM). Has also been shown to inhibit bovine chymotrypsin A-gamma.

Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.