Chemicals & Small Molecules

Taltobulin, a synthetic analog of the tripeptide hemiasterlin, serves as a robust cytotoxic payload in the development of antibody drug conjugates (ADCs). Taltobulin inhibits the polymerization of purified tubulin, causing disruption in microtubule organization within cells, leading ultimately to apoptosis. Reagent grade, for research purpose.

Tubulysin A (TubA), an antibiotic derived from myxobacteria, acts as an antibody drug conjugate (ADC) payload. Belonging to a family of nine cytotoxic peptides (A-I), Tubulysin A exhibits anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative properties. Reagent grade, for research purpose.

SG3199 serves as a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer, functioning as the liberated warhead in the ADC payload Tesirine. Reagent grade, for research purpose.

Fmoc-OtBu-Glu-PEG4-Azide is a peptide linker which may be applied in the development of antibody drug conjugates (ADCs). The t-butyl group can be deprotected under acidic conditions. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The PEG4 linker enhances the hydrophilicity of the conjugated compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3,4-Dibromo-Mal-PEG4-Val-Cit-PAB-MMAE serves as a peptide linker that can be used in the creation of antibody drug conjugates (ADCs). The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The cathepsin-cleavable Val-Cit-PAB dipeptide is ligated to an MMAE payload. The PEG4 chain improves the water-solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

1-(pentan-5-dipropylamine)-1-hydroxyl-1,1-bis(TBDMS-hexane)

Azide-PEG-Fluor 488, MW 2,000 is a powerful green-fluorescent dye used in Click Chemistry reactions. It will react with the DBCO or other alkyne group in antibody, proteins, peptides, amino-modified oligos, and other target molecules. The dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. The average MW of the dye and the polyethylene glycol chain is 2,000. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DM4-SPDB-acid serves as a drug-linker conjugate comprised of the maytansine-derived payload DM4, known for its tubulin-inhibiting properties, linked via an SPDB linker, resulting in a highly effective treatment with strong anti-tumor capabilities. It is suitable to be conjugated into antibody-drug conjugates (ADCs). The terminal carboxylic acid can react with primary amine groups in the presence of activators such as HATU. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

D-Glu-OtBu-PEG4-azide functions as a peptide linker containing glutamic acid, which is also protected by a terminal t-butyl ester that can be deprotected under acidic conditions. Glutamic acid is an α-amino acid that is used in the biosynthesis of proteins. The PEG4 linker enhances the water solubility of the compound and assists in fine-tuning DMPK properties. Azides are a click chemistry handle used to react with terminal alkynes or strained cyclooctynes. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.