Chemicals & Small Molecules

Dye set for testing the properties of phase separated droplets, Stain for proteins and amyloids with strong hydrophobic interactions in droplets, Includes dyes for detection of droplet to aggregate conversion

Pasteurella Multocida Toxin

PERTUSSIS TOXINS AND VIRULENCE FACTORS

FOXO1-IN-3 is a highly-selective, orally active inhibitor of FOXO1 that reduces hepatic glucose production and improves insulin sensitivity and glucose regulation in db/db mice, without causing weight gain.

Gliocidin (62289-81-0) is a nicotinamide-mimetic prodrug that targets de novo purine biosynthesis vulnerability in glioblastoma (IC50 = 150 nM). Gliocidin was converted via the NAD+ salvage pathway to gliocidin-adenine dinucleotide with directly interfered with the activity of IMPDH2 resulting in guanylate depletion and cell death. Displays strong blood brain barrier permeability and suppression of glioblastoma in athymic nude mice. Gliocidin showed synergistic effects with temozolomide. Inhibitor of the SARS 3CLPRO protease.