Chemicals & Small Molecules

Cy7 diacid is a near-infrared fluorescent dye containing two non-activated, free carboxylic acid groups.

DXD, an Exatecan derivative that is a potent DNA topoisomerase I inhibitor, may be used as a payload in HER2-targeting antibody drug conjugates (ADCs).

N-Ethyl-N',N'-dimethylpropane-1,3-diamine is a compound comprised of a secondary and a tertiary amine. Reagent grade, for research use only.

AR-42, also called OSU-HDAC42, is a powerful inhibitor of histone deacetylase (HDAC). It effectively stops HDAC activity, leading to increased acetylation of histone H3, α-tubulin, and an up-regulation of p21. HDAC inhibitors focus on HDAC enzymes, and they are applied in cancer research. Reagent grade, for research purpose.

4-Azido-L-phenylalanine

BP Fluor 647-PEG10-azide is a water-soluble, far-red fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. A significant advantage to using long wavelength dyes such as Cy5 or BP Fluor 647 dye over other fluorophores is the low autofluorescence of biological specimens in this region of the spectrum. The azide reacts with strained cyclooctynes such as BCN, DBCO via a copper-free "click chemistry" reaction. The brightness and photostability of this dye are best suited to direct imaging of low-abundance targets. The PEG10 enhances water-solubilty and fines tunes the biological activity of the labeled products.

1-(pentan-5-ol)-2-hydroxyl-3,4-bis(TBDMS-hexane)

BP Fluor 647 carboxylic acid is a bright green-fluorescent dye optimal for use with the 633, 650 nm Argon laser. The compound's sulfonate groups permit hydrophilicity and less aggregation in the aqueous solution. BP Fluor 647 is used for protein and antibody labeling, or nucleic acid applications with high labeling density. The carboxyl group can react with amines via coupling agent (e.g. HATU).

N-(Propargyl-PEG2)-DBCO-PEG3-NHS ester is a PEG linker with a terminal NHS ester to perform facile reactions with amine groups of molecules as well as a propargyl to react with azides to form a triazole. The DBCO can participate in copper-free Click Chemistry reactions.