Chemicals & Small Molecules

Gly-Gly-Gly-PEG7-methyltetrazine is a tripeptide featuring three glycine residues. The methyltetrazine can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures. The PEG7 spacer imparts aqueous solubility of the compound.

503O13 is a biodegradable lipid-like compound designed for the delivery of siRNA.

7-O-(Azido-PEG4)- paclitaxel posseses paclitaxel moiety. The azido group is reactive towards BCN, DBCO, alkyne. The hydrophilic PEG spacer makes the compound more compatible in aqueous media.

Val-Cit-PAB-Exatecan is an enzymatically cleavable peptide with an exatecan payload, and it is used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B.

MC-Val-Cit-PAB-Exatecan is a cleavable ADC linker containing a Val-Cit dipeptide, PAB motif, and Exactecan. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety.

DBCO-PEG2-Val-Cit-PAB-Exatecan is a cleavable ADC linker. It includs a Cathepsin-cleavable Val-Cit dipeptide, PAB moeity, exatecan payload, and DBCO group; A click chemistry handle that readily reacts with azide groups. The PEG2 chain increases the hydrophilicity of the compound.

BP Fluor 647-PEG-CH2CO2-NHS, MW 2,000

Fmoc-L-Glu(OAll)-Val-Cit-PAB-MMAE functions as an Fmoc-protected tripeptide linker-payload in the employment of antibody drug conjugates (ADCs)

Bis-sulfone-PEG2-Bis-sulfone consists of four sulfone groups which can be conjugated with thiol groups of proteins and a PEG2 spacer for improved water-solubility of the compound.