Chemicals & Small Molecules

5-bromopentyl 2-octyldecanoate

DBCO-trimethoxysilane contains DBCO to react with azide-bearing compounds or biomolecules to form a triazole linkage and a triethoxysilane to react with surface-bearing hydroxyl groups, resulting in a substitution reaction at silicon.

L-Glu(OAll)-Val-Cit-PAB-MMAE

DBCO-Val-Cit-PAB-OH represents a precursor of antibody drug conjugates (ADCs). It posseses a chemically labile Val-Cit dipeptide, highly-reactive DBCO group for copper-free click reactions, and a benzylic alcohol that can be used to attach with reactive groups such as PNP for conjugation with drug payloads.

N-(Azido-PEG4)-N-bis(PEG4-Val-Cit-PAB-MMAE) is a dual linker-payload containing an azide handle that is free to perform click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The two linker-payloads each include the cathepsin-cleavable Val-Cit-PAB dipeptide ligated to an MMAE payload which is an efficiently released toxin to target cells to cause cellular apoptosis.

DSPE-PEG5-azide is a PEG linker. The hydrophobic features of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker enhances the water solubility of the overall compound allowing for the delivery of the drug. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN.

Acid-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker comprised of a carboxylic acid, a hydrophilic PEG spacer, and a chemically labile Val-Cit-PAB dipeptide ligated to an MMAE payload. Carboxylic acids reacts with amines or alcohols while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.

Fmoc-cys(npys)-OH

(2R,3S)-3-(tert-Butoxy)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)butanoic acid