Chemicals & Small Molecules

sulfo-Cy5 tyramide, a far-red fluorescent dye, is crucial for enhancing fluorescence via tyramide signal amplification (TSA) in immunohistochemistry, immunocytochemistry, and fluorescence in situ hybridization (FISH). Sulfo-Cy5 tyramide can be used with HRP-conjugated molecules, such as antibodies or streptavidin, for immunofluorescence staining of cells and tissues.

Ac4ManNAl is a tetraacetylated N-(4-pentynoyl)-mannosamine, is an alkyne-labeled monosaccharide used for studying glycoproteins. It's cell-permeable and replaces the natural monosaccharide ManNAc intracellularly. This metabolic labeling tool allows specific detection of glycoproteins. Detection is achieved via Cu(I)-catalyzed click reaction (CuAAC) with fluorescent-labeled azides or biotin-azide, providing insight into glycoprotein dynamics in vivo.

L-Homopropargylglycine (HPG) is a noncanonical amino acid analog of methionine featuring a terminal alkyne group. HPG is cell-permeable and randomly integrates into growing proteins during translation, replacing methionine. The resulting alkyne-labeled full-length proteins can be identified through copper-catalyzed click reactions with fluorescent or biotin-labeled azides. These labeled proteins are then suitable for various applications such as microscopic imaging or purification.

This reagent is a modified lipid containing an omega-terminal azide. The terminal azide group can be used in a highly specific linking reaction with alkyne-containing reagents, known as ‘click chemistry’, in the presence of a copper (Cu)-containing catalyst.

A1V2PF1-NHEt is an IAP-recruiting ligand, designed via in silico methods, used for targeted protein degradation and in SNIPER technology development.

A1V2PF2-NHEt is an IAP-recruiting ligand, designed through in silico methods, used for targeted protein degradation and in the development of SNIPER-based protein erasers.

VHL Ligand 8 is a small molecule ligand for the VHL E3 ligase, serving as a key component in the synthesis of ARD-266, a potent PROTAC degrader targeting the androgen receptor (AR). ARD-266 facilitates AR degradation in specific cell lines, with a high degree of efficiency, indicated by DC50 values ranging from 0.2 to 1 nM. This highlights the usefulness of VHL Ligand 8 in developing targeted protein degradation tools.

Nutlin-3 is a commercially available inhibitor that specifically targets the interaction between p53 and MDM2, leveraging its structural properties to modulate this protein-protein interaction.

Nutlin carboxylic acid (MDM2 ligand 1) is a Nutlin 3-derived ligand specific for MDM2. It can be linked to a target protein via a linker to create a PROTAC, enabling targeted protein degradation.