Chemicals & Small Molecules

Duocarmycin TM (CBI-TMI) functions as a robust antitumor antibiotic with the capability to induce sequence-selective alkylation of duplex DNA. Its crucial role lies in serving as a cytotoxic payload during the development of antibody drug conjugates (ADCs). Reagent grade, for research purpose.

Duocarmycin MA is a DNA minor-groove-binding alkylating molecule. It may be used as a payload in the development of antibody–drug conjugates (ADCs). Reagent grade, for research purpose.

(S)-Seco-Duocarmycin SA serves as a DNA alkylator, demonstrating cytotoxicity against cancer cells. Additionally, it functions as an ADC payload in the context of antibody-drug conjugates.

Seco-DUBA represents a prodrug of duocarmycin (DUBA) featuring two hydroxyl groups, each available for coupling to an antibody through a linker. Its application extends to the synthesis of antibody-drug conjugates (ADCs). Reagent grade, for research purpose.

Duocarmycin Analog, derived from Duocarmycin, serves as a DNA alkylator and functions as a cytotoxin in antibody-drug conjugates (ADCs). Reagent grade, for research purpose.

Taltobulin, a synthetic analog of the tripeptide hemiasterlin, serves as a robust cytotoxic payload in the development of antibody drug conjugates (ADCs). Taltobulin inhibits the polymerization of purified tubulin, causing disruption in microtubule organization within cells, leading ultimately to apoptosis. Reagent grade, for research purpose.

Tubulysin A (TubA), an antibiotic derived from myxobacteria, acts as an antibody drug conjugate (ADC) payload. Belonging to a family of nine cytotoxic peptides (A-I), Tubulysin A exhibits anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative properties. Reagent grade, for research purpose.

SG3199 serves as a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer, functioning as the liberated warhead in the ADC payload Tesirine. Reagent grade, for research purpose.

Fmoc-OtBu-Glu-PEG4-Azide is a peptide linker which may be applied in the development of antibody drug conjugates (ADCs). The t-butyl group can be deprotected under acidic conditions. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The PEG4 linker enhances the hydrophilicity of the conjugated compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.