Chemicals & Small Molecules

3,4-Dibromo-Mal-PEG4-Val-Cit-PAB-MMAE serves as a peptide linker that can be used in the creation of antibody drug conjugates (ADCs). The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The cathepsin-cleavable Val-Cit-PAB dipeptide is ligated to an MMAE payload. The PEG4 chain improves the water-solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

1-(pentan-5-dipropylamine)-1-hydroxyl-1,1-bis(TBDMS-hexane)

Azide-PEG-Fluor 488, MW 2,000 is a powerful green-fluorescent dye used in Click Chemistry reactions. It will react with the DBCO or other alkyne group in antibody, proteins, peptides, amino-modified oligos, and other target molecules. The dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. The average MW of the dye and the polyethylene glycol chain is 2,000. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DM4-SPDB-acid serves as a drug-linker conjugate comprised of the maytansine-derived payload DM4, known for its tubulin-inhibiting properties, linked via an SPDB linker, resulting in a highly effective treatment with strong anti-tumor capabilities. It is suitable to be conjugated into antibody-drug conjugates (ADCs). The terminal carboxylic acid can react with primary amine groups in the presence of activators such as HATU. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

D-Glu-OtBu-PEG4-azide functions as a peptide linker containing glutamic acid, which is also protected by a terminal t-butyl ester that can be deprotected under acidic conditions. Glutamic acid is an α-amino acid that is used in the biosynthesis of proteins. The PEG4 linker enhances the water solubility of the compound and assists in fine-tuning DMPK properties. Azides are a click chemistry handle used to react with terminal alkynes or strained cyclooctynes. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azido-PEG4-Glu-Gly-Cit-PAB-OH is a cleavable tripeptide linker, exhibiting exceptional stability in the bloodstream, resisting degradation and human neutrophil protease cleavage, while still enabling the intracellular release of payloads in a discrete, traceless drug-release manner. It consists of an azide handle for click chemistry reactions with terminal alkynes or strained cyclooctynes as well as a PEG4 linker for improved hydrophilicity. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azido-PEG23-Ms is a bifunctional PEG linker possessing a mesyl that acts as a good leaving group for nucleophilic substitution reactions and azido to react with BCN, DBCO, and alkyne to form a triazole linkage. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Biotin-2-sulfopropanoic acid, TEA salt functions as a biotinylation reagent, where the carboxylic acid and the primary amine are free to link this molecule to larger structures, while the sulfonate group provides high water solubility to the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

NH2-PEG-acid HCl salt, MW 2,000 serves as a bifunctional polymer PEG containing a terminal amine that is reactive with NHS or carboxylic acid in the presence of HATU or EDC and a carboxylic acid which may be further derivatized for conjugation. The 2k PEG polymer improves the water solubility of the molecule. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.