Chemicals & Small Molecules

tert-butyl 16-hydroxyhexadecanoate

BDP FL-PEG8-acid is a BDP FL acid linker containing a hydrophilic PEG spacer arm. BDP FL is a green-fluorescent dye and the hydrophilic PEG spacer arm increases water solubility as well as membrane permability. BDP FL dye has several characteristics that make it potentially superior in some applications, including high extinction coefficient, high fluorescence quantum yield, narrow emission bandwidth, red shift in fluorescence emission at high dye concentrations, relatively long excited-state lifetime, etc. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

AMCA-PEG1-acid is a fluroescent reagent with a terminal carboxylic acid group. The hydrophilic PEG spacer arm increases water solubility, membrane permability, and conjugation efficiency. AMCA-PEG1-acid is a popular blue fluorescent tagging molecule that has a maximal absorption of 345 nm and emission at 450 nm. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

AMCA-PEG4-acid is a fluroescent reagent with a terminal carboxylic acid group. The hydrophilic PEG spacer arm increases water solubility, membrane permability, and conjugation efficiency. AMCA-PEG4-acid is a popular blue fluorescent tagging molecule that has a maximal absorption of 345 nm and emission at 450 nm. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

NHS ester-Val-Cit-PAB-MMAE serves as a precursor of antibody-drug conjugates (ADCs). It contains a cathepsin-cleavable Val-Cit dipeptide and MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody which directs it toward cancer cells. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bromide-Val-Cit-PAB-MMAE is a synthetic antibody-drug conjugate (ADC) coupled to a bromide group, which is a very good leaving group for nucleophilic substitution reactions. It contains a protease-sensitive Val-Cit dipeptide and an MMAE payload, which is a synthetic antineoplastic agent that can be attached to a monoclonal antibody (mAb) for targeting cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

nonadeca-1,18-dien-10-ol

BDP FL-PEG8-NHS ester is a BDP dye linker containing a NHS ester group and a hydrophilic PEG spacer arm. The NHS ester allows the dye to react with primary amines and the hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing and is photostable. BDP FL-PEG8-NHS ester is a green-fluorescent dye and has several characteristics that make it potentially superior in some applications, including high extinction coefficient, high fluorescence quantum yield, narrow emission bandwidth, red shift in fluorescence emission at high dye concentrations, relatively long excited-state lifetime, etc. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Azide-Val-Cit-PAB-OH functions as a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. The azide moiety participates in copper-catalyzed Click Chemistry reactions with alkyne, DBCO, and BCN. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.