Chemicals & Small Molecules

Azide-PEG4-Val-Cit-PABC-Exatecan is an enzymatically cleavable linker-payload conjugate, and it can be used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. Exatecan is a structural analog of camptothecin and shows anticancer activity. The azide group can react with alkyne, BCN, and DBCO via Click Chemistry.

Sulfo TCO-Maleimide is a water-soluble reagent for attaching TCO moieties to cysteine-containing peptides or other thiol-containing molecules. The maleimide group selectively reacts with reduced thiols at pH 6.5-7.5, forming stable thioether bonds. The hydrophilic sulfonated spacer enhances water solubility, and the short spacer arm adds minimal mass to the modified molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Iodoacetamide alkyne is a cysteine-reactive probe that covalently binds cysteine residues in proteins and peptides to an alkyne group. The alkyne can be used in click chemistry to attach fluorophores or biotin, allowing visualization by in-gel fluorescence or identification by mass spectrometry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Bromoacetamido-PEG12-Tris(-PEG11-bromoacetamide) functions as a branched PEG linker, where the terminal bromo groups are good leaving groups for nucleophilic substitution reactions. The PEG links raise the solubility of the molecule in aqueous media and assist in optimizing DMPK properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

MAL-PEG24-amido-PEG24-amido-PEG24-DSPE includes DSPE connected via hydrophilic PEG arms to maleimide, which will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophobic DSPE encapsulates hydrophobic drugs, while the hydrophilic PEG arms improve water solubility for effective drug delivery.

Azide-PEG4-Val-Cit-PAB-SN-38 serves as a cleavable ADC linker conjugated to SN-38, an anti-tumor drug and active metabolite of irinotecan. SN-38 inhibits DNA topoisomerase I, halting DNA synthesis and causing single-strand breaks. The Val-Cit linker is cleaved by lysosomal Cathepsin B, ensuring targeted intracellular release. The azide group participates in copper-catalyzed click chemistry with alkyne, DBCO, and BCN. The PEG spacer imparts water solubility to the molecule and helps optimize DMPK properties.

PC-PEG3-biotin functions as a biotinylating reagent featuring a photocleavable moiety and terminal biotin which can react with amine molecules in the presence of activators like EDC or HATU. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. The PEG3 spacer imparts hydrophilicity. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

AMCA-PEG1-amide-PEG4-Azide is a fluroescent reagent with an azide group for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. The hydrophilic PEG spacer arm increases water solubility, membrane permability, and conjugation efficiency. The additional amide bond could potentially introduce the hydrogen bonding and beneficial some specific applications. AMCA-PEG1-amide-PEG4-Azide is a popular blue fluorescent tagging molecule that has a maximal absorption of 345 nm and emission at 450 nm. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

AMCA-PEG4-Azide is a fluroescent reagent with an azide group for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. The hydrophilic PEG spacer arm increases water solubility, membrane permability, and conjugation efficiency. AMCA-PEG4-Azide is a popular blue fluorescent tagging molecule that has a maximal absorption of 345 nm and emission at 450 nm. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.