Chemicals & Small Molecules

AMCA-PEG4-DBCO is a AMCA dye containing a reactive DBCO group and a hydrophilic PEG spacer arm with excitation/emission maximum of 345/450 nm. DBCO reacts with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalysts. It could be used as a quantum yield standard. Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

TCO-PEG2-NHS ester serves as a heterobifunctional PEG linker comprised of a TCO click chemistry handle that readily reacts with tetrazine groups and NHS ester that directly and efficiently reacts with amine-bearing molecules. The PEG spacer imparts water solubility.

t-Boc-N-MMAF

Biotin-PEG11-NHCO-MMAF-N-t-Boc functions as a biotinylation reagent with the biotin moiety linked to an MMAF payload protected by a Boc group which can be removed under acidic conditions to reveal the free amine. The connecting PEG arm enhances the water-solubility of the compound.

Biotin-PEG11-NHCO-MMAF-N-t-Boc acts as a biotinylation reagent with the biotin moiety linked to an MMAF payload for antibody-drug conjugates (ADCs) via a PEG chain that improves the hydrophilicity of the molecule.

AMCA-PEG8-Mal is a AMCA dye linker containing a maleimide group, which selectively reacts with free thiol, sulfhydryl, or mercapto group via Michael addition to form a stable carbon sulfur bond. The hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Exatecan-2-(aminomethoxy)acetamide-Gly-Phe-Gly-Gly-PEG2-endo-BCN represents a tetrapeptide derivative which may be employed in the development of antibody drug conjugates (ADCs). The BCN group is a click chemistry handle which readily reacts with azide groups on a target molecule. Exatecan is a structural analog of camptothecin and shows anticancer activity. The PEG2 spacer imparts hydrophilicity.

DBCO-PEG-2-Val-Cit-PAB-OH constitutes a cleavable ADC linker. The Val-Cit was designed specifically to be cleaved by Cathepsin B. The DBCO moiety engages in copper-free catalyzed click chemistry with azido-bearing moieties.

AMCA-PEG8-Amine, TFA salt is a AMCA dye linker containing an amine group and a hydrophilic PEG spacer arm. The amine group makes the compound more reactive toward carboxylic acids, NHS esters and other carbonyl groups. The hydrophilic PEG spacer arm increases water solubility as well as membrane permability. This dye is used for protein and peptide labeing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.