Chemicals & Small Molecules

This reagent is a modified lipid containing an omega-terminal azide. The terminal azide group can be used in a highly specific linking reaction with alkyne-containing reagents, known as ‘click chemistry’, in the presence of a copper (Cu)-containing catalyst.

A1V2PF1-NHEt is an IAP-recruiting ligand, designed via in silico methods, used for targeted protein degradation and in SNIPER technology development.

A1V2PF2-NHEt is an IAP-recruiting ligand, designed through in silico methods, used for targeted protein degradation and in the development of SNIPER-based protein erasers.

VHL Ligand 8 is a small molecule ligand for the VHL E3 ligase, serving as a key component in the synthesis of ARD-266, a potent PROTAC degrader targeting the androgen receptor (AR). ARD-266 facilitates AR degradation in specific cell lines, with a high degree of efficiency, indicated by DC50 values ranging from 0.2 to 1 nM. This highlights the usefulness of VHL Ligand 8 in developing targeted protein degradation tools.

Nutlin-3 is a commercially available inhibitor that specifically targets the interaction between p53 and MDM2, leveraging its structural properties to modulate this protein-protein interaction.

Nutlin carboxylic acid (MDM2 ligand 1) is a Nutlin 3-derived ligand specific for MDM2. It can be linked to a target protein via a linker to create a PROTAC, enabling targeted protein degradation.

VH032-OH is a VH032-derived VHL ligand that can be linked to a protein-targeting ligand via a linker to create PROTACs, facilitating targeted protein degradation.

Caylin-1 is an analog of Nutlin-3 that functions as an MDM2 inhibitor. It also demonstrates binding affinity to Bcl-XL and has applications in studying multi-target protein interactions.

PROTAC MDM2 Degrader-2 is a compound designed to degrade MDM2 using PROTAC technology. It features a strong MDM2 inhibitor, a linker, and a ligand that targets E3 ubiquitin ligase, facilitating the targeted degradation of MDM2. This structural design enhances its effectiveness in modulating protein levels within cellular pathways.