Chemicals & Small Molecules

HIV-1 TAT (48-60) Acetate, a commonly used membrane-permeable carrier peptide, is an arginine-rich basic peptide derived from the human immunodeficiency virus (HIV-1 Tat) protein that enables intracellular delivery of compounds.

Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) is a cyclic pentapeptide, a cyclic RGD polypeptide with high affinity for αvβ3, which is capable of disrupting cellular integrin interactions. Cyclo(RGDfC) TFA inhibits pluripotent gene expression in embryonic stem cells (ESCs) and inhibits tumorigenic potential of mESCs in vivo. Cyclo(RGDfC) TFA inhibits the tumorigenic potential of mESC. Cyclo(RGDfC) TFA can be used for tumor-related studies.

Alcohol dehydrogenase, a dimeric protein located in the cytosol of cells, serves as the primary enzyme for metabolizing alcohol in the body, with its highest expression in the liver. It plays a crucial role in the detoxification of environmental alcohol [1].

β-Glucosidase is a glucoside bond hydrolase widely found in organisms and is involved in glucose metabolism, which can be used to study diseases caused by abnormal glucose metabolism.

Aldehyde dehydrogenase NAD(P) (ALDH) is an enzyme that facilitates the conversion of aldehydes into their respective carboxylic acids while simultaneously reducing the cofactor NAD(P) to NAD(P)H, making it a key component in biochemical research. This enzyme plays a crucial role in mitigating aldehyde stress by being part of the body's array of enzymatic defenses [1].

Neuraminidase, Microorganism (Exo-α-sialidase) is a sialidase that catalyzes the hydrolysis of sialic acid, has antigenic properties, and assists in the separation of mature influenza viruses from the host cell to infect new cells.Sodium caseinates is used as a thickening and emulsifying agent in the food industry.

Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of the human microtubule-associated protein tau and targets tau protein by binding to amino acid residues at the N-terminal end of tau protein. Tilavonemab blocks the ability of human and mouse neurons to uptake tau aggregates and can be used to study neurological diseases.

Olokizumab (CDP-6038) is a humanized anti-IL-6 monoclonal antibody that selectively blocks the final assembly of the IL-6 signaling complex for the study of rheumatoid arthritis (RA).

Brontictuzumab (OMP 52M5) is a monoclonal antibody that targets Notch1 and inhibits activation of the pathway. It has antitumor activity, inhibits tumor cell proliferation, and can be used in the study of leukemias and lymphomas.