Chemicals & Small Molecules

BEBT-109 is a potent selective inhibitor of pan-mutant EGFR with enhanced pharmacokinetic properties, suitable for research on various mutant-EGFR-driven non-small cell lung cancer (NSCLC) [1].

TCRS-417 (T417), a small molecule compound, selectively binds to the interface between PBX1 and its specific DNA target sequence, disrupting the PBX1-DNA interaction. This compound has potential research applications in cancer, developmental, inflammatory, autoimmune, and neurodegenerative diseases [1].

Peimisine 3-O-β-D-glucopyranoside is a steroidal alkaloid isolated from the bulb of Monocarpus monocarpus with partial neuroprotective activity, and can be used for the study of rotenone-induced neurotoxicity in the PC12 cell line.

Obexelimab (XmAb5871) is a bifunctional monoclonal antibody that binds CD19 and FcyRIIb, inhibits B-cells, plasmoblasts, and plasma cells, and may be used in the study of autoimmune diseases such as systemic lupus erythematosus.

Marstacimab (PF-06741086) is a neutralizing antibody that binds to and inhibits inhibitors of the human tissue factor pathway. Marstacimab is an anti-tissue factor pathway inhibitor used in the study of hemophilia.

Hydrogenated soya phosphatidylcholines, a natural compound, enhances the controlled release of water-soluble drugs in oral drug delivery systems by improving drug loading and solubility [1].

Acetylthevetin A, a natural product, is isolated from the oleander (Cascabela thevetioides) [1].

12-Doxyl stearic acid, a derivative of stearic acid featuring a 4,4-dimethyl-3-oxazolinyloxy (DOXYL) group, functions as a hydrophobic spin label. This compound is prevalently utilized in research to investigate the molecular characteristics of membranes and hydrophobic proteins.

DC4 crosslinker, an 18Å mass spectrometry-cleavable crosslinking reagent, features two intrinsic positive charges facilitating the fragmentation of cross-linked peptides into their constituent peptides through collision-induced dissociation or in-source decay. Initial fragmentation leads to cleavage adjacent to the positive charges, enabling the identification of cross-linked peptides as pairs of ions with precise mass separation. Furthermore, the resultant intact peptide fragments can undergo further fragmentation, producing a sequence of b- and y-ions for peptide identification.