Chemicals & Small Molecules

NTPO trisodium induces DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. Its DNA damaging effects are mitigated by base excision repair (BER) but not by nucleotide excision repair (NER) [1].

Rose bengal lactone (C.I. Solvent Red 141) is a rose bengal lactone stain commonly used to stain the nuclei of plant and animal cells.

Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is employed for labeling proteins on the external leaflet of intact exosomes and features an extended spacer arm between the biotin and the amine-reactive linker. This elongated linker is designed to mitigate steric hindrance, thereby enhancing labeling efficiency on the densely populated exosome surface [1] [2].

TI17, an inhibitor of the thyroid hormone receptor-interacting protein Trip13, possesses anticancer activity by effectively inhibiting multiple myeloma (MM) cell proliferation and inducing cell cycle arrest and apoptosis. Trip13, an AAA-ATPase mediating double-strand break (DSB) repair, is inhibited by TI17, resulting in increased DNA damage [1].

Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.

Pan-RAS-IN-2 (compound 6A) is a molecular glue that specifically targets RAS molecules, exhibiting significant inhibitory activity on the proliferation of RAS-mutated cell lines. It forms a ternary complex with cyclophilin A (CYPA) and RAS(ON) proteins, which blocks the downstream binding of RAF to RAS, thereby exerting antitumor effects.

PTPN2-IN-1 (compound 4) acts as a potent inhibitor of PTPN2, demonstrating an IC 50 of less than or equal to 5μM. It effectively inhibits the cell growth of B16F10.

Linolenyl alcohol, an unsaturated alcohol, has properties that inhibit Gram-positive bacteria.

Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) acts as an inhibitor of both HIV-1 integrase (IN) and HIV-1 reverse transcriptase ribonuclease H (RT RNase H), exhibiting IC50 values of 6.32 µM and 5.9 µM, respectively.