Activators & Inhibitors

AMG-193 (compound 481) acts as an inhibitor of PRMT5, and PRMT5-IN-27 is effective in halting the proliferation of HCT116 cells, exhibiting an IC50 value of 0.13 μM [1].

ATF4-IN-2 (Compound 29), an ATF4 inhibitor, exhibits an IC50 value of 47.71 nM and can be utilized in the research of neurodegenerative diseases [1].

DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.

JJC8-091 is a powerful DAT inhibitor, useful for researching psychostimulant use disorders [1].

LC-MB12 is an orally active, selective and potent PROTAC FGFR2 complex that degrades FGFR2.LC-MB12 has antiproliferative and antitumor activity.LC-MB12 is used in the study of gastric cancer because of its inhibition of FGFR2 signaling.LC-MB12 has been shown to have antiproliferative and antitumor activity.LC-MB12 has been shown to have antiproliferative and antitumor activity.

Sulfo-CY-5.5 NHS ester (Sulfo-Cyanine5.5 NHS ester) tripotassium is a sulfonated far-red Cyanine5.5 fluorophore ester that reacts with amines. It is commonly used to label antibodies, proteins, and other molecules for in vivo NIR imaging [1].

AXC-666 is a TLR agonist and an immuno agonist that can be used to synthesize antibody drug couplers (ADCs).

Pyrroline-5-carboxylate sodium is a naturally occurring intermediate and a potent activator of redox-dependent metabolic pathways and a PROTAC linker.