Activators & Inhibitors

Substance P acetate is a peptide mainly secreted by neurons and is involved in many biological processes including nociception and inflammation. Substance P acetate is a neuroinflammatory factor that can act as a neurotransmitter and neuromodulator in the central nervous system and can be used to study cardiovascular and neurological diseases.

Cyclolinopeptide A is a cyclic nonapeptide extracted from linseed oil.

Human serum albumin (HSA), the most abundant protein in plasma, significantly contributes to plasma oncotic pressure and exhibits antioxidant, anticoagulant, anti-inflammatory, and anti-platelet aggregation activities, as well as colloid osmotic action. It can block the inhibitory effect of GML on human T cells, providing a protective function, and is associated with cardiovascular diseases. HSA partially prevents LPS-induced oxidative stress and the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO −) in the vascular wall, helping to reduce blood pressure [1] [2] [3].

Vipivotide tetraxetan Linker (PSMA-617 Linker) is a noncleavable peptide linker utilized in the synthesis of Vipivotide tetraxetan (PSMA-617), a ligand instrumental in producing 177Lu-PSMA-617. This radioactive molecule is applied in the treatment of prostate cancer[1].

Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum.

Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits the uptake of 22Na+ by fibroblasts expressing human NHE-1 in a concentration-dependent manner, inhibits platelet swelling, and can be used in the study of cardiovascular diseases.

Wnt pathway; Stem cells

Kinase inhibitors, EGFR; Cancer