Labelling

Indocyanine Green (aka ICG, IC Green, Foxgreen) is used for reliable imaging and flow cytometry. This dye is water-soluble and pH-insensitive. The fluorescence of Indocyanine Green is not visible to the human eye but is readily detected by most imaging systems. Indocyanine Green binds tightly to plasma proteins and becomes confined to the vascular system. The dye has a half-life of 150 to 180 sec and is removed from circulation exclusively by the liver to bile juice. Indocyanine Green is used for determining cardiac output, hepatic function, liver and gastric blood flow, and for ophthalmic angiography.

TechnoDye 498/505 is a water soluble fluorophore. Its absorption and emission spectra are similar to fluorescein, but it is fluorescent in acidic media, and it is much more stable against photobleaching and oxidation.

Thiazole Orange is an asymmetric cyanine dye whose fluorescence highly depends on the local environment. Thiazole Orange is essentially dark in solution; however, its fluorescence increases a thousandfold when Thiazole Orange is introduced into double-stranded DNA and RNA (dsDNA or dsRNA). The maximum absorption of Thiazole Orange in complex with DNA is 509 nm, and the maximum emission is 532 nm. Thiazole Orange solution is widely used for determining the percentage of reticulocytes in human peripheral blood with microscopy and flow cytometry. We also offer the ready-to-use solution of Thiazole Orange LumiCell Reticulocyte Stain for this purpose.

sulfo-Cyanine3 dimethyl is a non-functionalized, water-soluble cyanine dye with bright yellow fluorescence. The dye can be used as a non-reactive fluorophore for control experiments, calibration, and other technical applications.

sulfo-Cyanine5 dimethyl is a non-functionalized, water-soluble cyanine dye with bright far-red fluorescence. The dye can be used as a non-reactive fluorophore for control experiments, calibration, and other technical applications.

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Our potent and selective hα1A adrenergic receptor fluorescent antagonist shows high affinity for α1A adrenergic receptor (Ki =28.3 nM measured in radioligand binding assay) and selectivity over α2A (Ki =1081 nM measured in radioligand binding assay). It is potentially suitable for fluorescence-based assays such as confocal microscopy or high content screening.

Our potent and selective hα1A adrenergic receptor fluorescent antagonist shows high affinity for alpha 1 adrenergic receptor (Ki =5 nM measured in radioligand binding assay) and selectivity over α2A (15% of displacement at 1 μM in radioligand binding assay). It is potentially suitable for fluorescence-based assays such as confocal microscopy, high content screening or fluorescence polarization.

Our CELT-145 ligand is a highly potent fluorescent antagonist developed for hA1R testing with a Ki of 160 nM in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 63ml of 100nM working solution to test AT1R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-145 ligand is potentially suitable for other fluorescence-based assays such as HTRF.