Lipids

2,5-dioxopyrrolidin-1-yl 6-bromohexanoate is a chemical reagent featuring a bromide and an NHS ester at opposing ends of a saturated C6 chain. Bromide is easily displaced by nucleophiles such as amines, while the NHS ester readily reacts with amines under mild conditions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

4,4-bis(octyloxy)butanoic acid sodium salt is a chemical reagent featuring a butanoic acid and an acetal linking it to two identical saturated C8 tails. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

8-Bromo-octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester is a chemical reagent featuring a bromide and an NHS ester at opposing ends of a saturated C8 chain. Bromide is easily displaced by nucleophiles such as amines, while the NHS ester readily reacts with amines under mild conditions. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

2-(4-{2-[(2-aminoethyl)amino]ethyl}piperazin-1-yl)ethan-1-amine is a precuers for the synthesis of lipid C12-200 for LNP drug delievery. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Heptadecan-9-amine is a chemical reagent featuring a primary amine at the central position of a saturated C17 chain. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

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1-Aminoundecane is a chemical reagent featuring a primary amine and a saturated C11 tail. The primary amine is a versatile substrate which can be used to build a wide variety of bonds. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

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DODAP (18:1) is an ionizable lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). Reagent grade, for research use only.