Nucleotides

Beta-1-Methylpseudouridine is a substitute for uridine in modified mRNA and has been shown to increase transfection by reducing immuogenicity. Beta-1-Methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2-Thiouridine is a uridine derivative that acts as a precursor for protein synthesis. Reagent grade, for research use only.

2'-O-Methyladenosine is a nucleoside that is a low-energy analog of adenosine. Reagent grade, for research use only.

2'-O-Methylcytidine is a cytidine nucleoside derivative with a hydroxyl group on the 2' carbon. Reagent grade, for research use only.

2'-O-Methylguanosine is a guanosine nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, as well as present in relatively high concentrations in tissues, such as liver and muscle, where it is involved in metabolism or energy production. Reagent grade, for research use only.

3'-O-Methyladenosine is a monomethylated adenosine. It may help the regulation of blood pressure and central nervous system function by inhibitiong the activity of adenosine receptors. Reagent grade, for research use only.

3'-O-Methylcytidine is an cytidine nucleoside that is a component of RNA. 3'-O-Methylcytidine also inhibits bacterial growth through inhibition of ribosomal function, leading to reduced protein synthesis. Reagent grade, for research use only.

3'-O-Methylguanosine is a nucleoside present in guanine, demonstrating inhibitory properties against malignant brain tumors. Reagent grade, for research use only.

3'-O-Methyluridine is a nucleoside that can be used in the preparation of oligonucleotides and as a substrate for uridine phosphorylase. Reagent grade, for research use only.