Nucleotides

Non-nucleosidic modifier reagent for the synthesis of biotinylated oligos based on a hydroxyprolinol core. This phosphoramidite contains a dimethoxytrityl protective group for the purification of the resulting oligos on C18 cartridges, and reverse phase HPLC.

A compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.Abasic phosphoramidites are used in DNA and oligonucleotide synthesis.

Spacer phosphoramidite 18 (hexaethylene glycol phosphoramidite) is an amidite reagent for oligonucleotide synthesis. It provides a long hydrophilic linker that can be used for the synthesis of Scorpion-type qPCR probes, for spacing biotin from oligo strand, and for other applications requiring spatial separation of modifier and oligo.

Pyrene is a polycyclic aromatic hydrocarbon that is well-known for its ability to intercalate into DNA. Pyrene features intense blue fluorescence. Its parameters depend strongly on the fluorophore microenvironment. Therefore, fluorescence spectra of pyrene are used for the extraction of structural information about the site surrounding pyrene.

NH-bis(PEG8-OH) is a homobifunctional reagent containing two alcohols joined together by a secondary amine. The alcohols can be used in a variety of ways such as in forming esters with carboxylic acids, while the secondary amine can be used as a nucleophile in linking with ketones, aldehydes, and carboxylic acids. The PEG spacers make this molecule water-soluble, potentially altering its DMPK properties.

rU phosphoramidite is a TBDMS-protected phosphoramidite monomer used as a building block when syntheizing RNA.

DMT-2'-Fluoro-dG(Ib) Phosphoramidite is a modified nucleoside phosphoramidite with a fluorine on the 2' position and can be employed for oligonucleotide synthesis.

DMT-2'-Fluoro-dC(Bz) Phosphoramidite is a nucleoside phosphoramidite with a fluorine on the 2' position and a cytidine capped with a benzoyl functional group.

N4-Bz-5'-O-DMTr-2'-O-(N3-Tfa) aminopropyl cytidine 3'-CED phosphoramidite is a TBDMS-protected phosphoramidite monomer that can be exploited to create DNA or RNA nucleotides.