Nucleotides

Fludarabine is a purine nucleoside derivative that disrupts ribonucleotide reductase and DNA polymerase in blood cells. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP, and survivin expression. Fludarabine displays anticancer activity against human hematological malignancies in vivo. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Udp-alpha-d-galactose disodium salt is an endogenous nucleotide sugar. The compound is a donor substrate for galactosyltransferases employed in the biosynthesis of galactose-containing oligosaccharides. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Clevudine is a beta-L-nucleoside analog of thymidine with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil is the impurity of antiviral drug Clevudine, which is used for the treatment of Hepatitis B. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Flavin Adenine Dinucleotide Disodium Salt hydrate is an adenine-containing enzymatic redox cofactor. Also known as flavin cofactors and is critical electron transporter in living systems. FAD has been used as a predominant fluorophore to study unstained eosinophils, which exhibit autofluorescence compared to other leucocytes. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2,2'-Anhydro-1(B-D-arabinofuranosyl)uracil is a research tool for anticancer and antiviral studies. This works by inhibiting uridine phosphorylase, a key enzyme targeted by some antitumor drugs. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Cytidine 5'-monophosphate, also known as 5'-CMP, is a nucleotide that is used as a monomer in RNA. 5'-CMP is a key intermediate in the preparation of several nucleotide derivatives and is widely used in food and pharmaceutical industries. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Telbivudine is a synthetic molecule containing beta-L-configuration. Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Zebularine is a nucleoside analog of cytidine. It is a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.