Nucleotides

5-Methyluridine is a nucleoside that is used to inhibit the replication of cells. 5-Methyluridine inhibits cellular replication by binding to ribothymidine and uridine in the nucleus, which inhibities DNA and RNA synthesis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-Bromouridine is an energy-related metabolite that is a precursor of uridine. 5-Bromouridine binds to the nuclear DNA in cells, where it can act as a transcriptional regulator. 5-Bromouridine is used in the treatment of malignant brain tumors, where it can inhibit tumor growth by binding to the DNA of cancer cells and preventing the synthesis of proteins required for cell division. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-Iodo-2'-deoxyuridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. Capecitabine is a prodrug that is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU). Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Deoxyuridine 5'-monophosphate disodium salt is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. 2'-Deoxyuridine 5'-monophosphate disodium salt is also used in research as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Floxuridine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which is involved in the synthesis of DNA. Floxuridine has been shown to inhibit tumor growth in animal models by inhibiting the production of reactive oxygen species and upregulating tumor suppressor genes, such as p53. It also has inhibitory effects on enzymes that are involved in cell proliferation, such as protein kinase C and tyrosine kinases. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-Iodo-2'-deoxycytidine is an iodinated analog of deoxycytidine and acts as an anti-viral agent. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Didanosine is a purine analog. Didanosine is an anti-retroviral drug used in the treatment of HIV in ART therapy, it also may increase acetaminophen related hepatotoxicity by enhancing mitochrondrial dysfunction. 2',3'-Dideoxyinosine has also been shown to inhibit the replication of other viruses such as herpes simplex virus type 1 and hepatitis B virus. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-O-(2-Methoxyethyl)-cytidine is a cytidine derivative that can be used as a building block for crosslinking oligonucleotides. 2'-O-(2-Methoxyethyl)-cytidine is also used as a texturizing agent in food products. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.