Chemicals & Small Molecules

Extracellular death factor (EDF) is a linear pentapeptide that initiates the cell death pathway in specific communicating cells. In bacteria, programmed cell death is regulated through quorum sensing, a cell-to-cell communication system. EDF is sensitive to extreme pH, high temperatures, and other cellular stressors. At a concentration of 2.5 ng/ml, EDF effectively induces cell death, significantly reducing population size in certain E. coli cultures.

FLLRN is a bioactive peptide that specifically acts as an antagonist for PAR1 (Protease Activated Receptor 1).

Chimmitecan exhibits remarkable efficacy both in vitro and in vivo as a powerful inhibitor of topoisomerase I. Reagent grade, for research purpose.

Rubitecan is an orally administered camptothecin that demonstrates anti-tumor efficacy. Reagent grade, for research purpose.

Karenitecin, characterized as a formidable topoisomerase I inhibitor, exhibits robust anti-cancer effects. It instigates DNA damage and elevates the protein expression of cyclin E and cdk2 in A253 cells.

Namitecan has been investigated in clinical trials focused on treating solid tumors. Functioning as a potent inhibitor of topoisomerase I, Namitecan possesses noteworthy antitumor properties. Reagent grade, for research purpose.

Lurtotecan, a semi-synthetic analog of camptothecin, stabilizes the topoisomerase I-DNA complex, inhibiting DNA replication and causing apoptosis through the formation of an enzyme-drug-DNA ternary complex. It also disrupts RNA synthesis, promotes the degradation of topoisomerase I, and alters chromatin structure, making it useful in PROTAC development for targeted cancer treatments.

(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione serves as a versatile building block for complex compounds, offering utility as an intermediate or foundational component for reactions with other chemical compounds. It is also an intermediate of Exatecan. Reagent grade, for research purpose.

N-(8-amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide, alternatively referred to as Exatecan Intermediate 2, serves as a crucial interim component in the synthesis of Exatecan. Exatecan is an anticancer agent classified among the camptothecin analogs.