Cytokines & Chemokines

This enzyme can be used to remove all forms of DNA and RNA, including double stranded, single stranded, linearized, and circular forms.

This enzyme can be used to remove all forms of DNA and RNA, including double stranded, single stranded, linearized, and circular forms.

GenScript’s offerings are cost-effective with reliable and proven performance for removal of contaminating nucleic acids. Furthermore, the Benz-Neburase’s offerings are produced under stringent quality controls with materials and manufacturing process that are fully traceable, allowing for support of IND filing and progression of development stages for various applications.

GenScript’s offerings are cost-effective with reliable and proven performance for removal of contaminating nucleic acids. Furthermore, the Benz-Neburase’s offerings are produced under stringent quality controls with materials and manufacturing process that are fully traceable, allowing for support of IND filing and progression of development stages for various applications.

GenScript’s offerings are cost-effective with reliable and proven performance for removal of contaminating nucleic acids. Furthermore, the Benz-Neburase’s offerings are produced under stringent quality controls with materials and manufacturing process that are fully traceable, allowing for support of IND filing and progression of development stages for various applications.

CD73, also known as ecto-5'-nucleotidase, is an enzyme that in humans is encoded by the NT5E gene.CD73 commonly serves to convert AMP to adenosine.The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. A  deficiency of CD73 occurs in a variety of immunodeficiency diseases.

CD73, also known as ecto-5'-nucleotidase, is an enzyme that in humans is encoded by the NT5E gene.CD73 commonly serves to convert AMP to adenosine.The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. A  deficiency of CD73 occurs in a variety of immunodeficiency diseases.

B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117 ) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling.