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      • Ref: BP-40690
        Sizes: 1 MG, 5 MG, 25 MG, 10 MG
        From: £137.00

        TCO (tetrazine – trans-cyclooctene) ligation is one of the fastest reactions used for bioconjugation. It is an inverse electron demand [4+2] cycloaddition that takes place between tetrazine and trans-cyclooctene or other strained olefins. sulfo-Cyanine5 tetrazine is a fluorophore derivative bearing a tetrazine group for the TCO-ligation-based labeling. This reagent possesses good aqueous solubility and stability in biological environments.

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      • Ref: BP-40691
        Sizes: 1 MG, 5 MG, 25 MG, 10 MG
        From: £137.00

        sulfo-Cyanine5.5 is a water-soluble, hydrophilic far-red fluorophore, an analog of Cy5.5®. Like other cyanine dyes, sulfo-Cyanine5.5 has an outstanding molar extinction coefficient, giving rise to its bright fluorescence. The molecule contains four sulfo groups that provide hydrophilicity and negative charge to the fluorophore and minimize non-specific binding. This reagent contains tetrazine moiety that reacts with trans-cyclooctenes, cyclopropenes, and some strained cyclooctynes to form stable conjugates via an inverted electron demand [4+2]-cycloaddition (IEDDA). The reagent possesses high aqueous solubility and hydrophilicity and is recommended for labeling biomolecules in an aqueous environment.

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      • Ref: BP-40692
        Sizes: 1 MG, 5 MG, 25 MG, 10 MG
        From: £137.00

        Dibenzocyclooctyne (DBCO, DBCO, ADIBO) is one of the most reactive cycloalkynes for copper-free click reaction (SPAAC, strain-promoted azide-alkyne cycloaddition). The rate of interaction of DBCO with azides is significantly higher than that of other cyclooctynes, as well as Cu-catalyzed click reaction (CuAAC). Unlike other cyclooctynes, DBCO does not interact with tetrazines, which makes it possible to use it in bioorthogonal reactions together with trans-cyclooctenes and tetrazines. BP Fluor 568 is a bright, photostable, and hydrophilic fluorophore that emits in the orange channel. The absorption maximum is 572 nm. The emission maximum is 598 nm. BP Fluor 568 DBCO allows fluorescent labeling of azide-containing biomolecules inside living cells and whole organisms without the negative effect of copper ions on them, and inanimate samples.

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      • Ref: BP-40693
        Sizes: 5 MG, 25 MG, 50 MG, 10 MG
        From: £262.00

        Strain promoted alkyne azide cycloaddition (SPAAC) between strained cycloalkynes and azides is a useful bioconjugation method that eliminates the need for copper catalyst necessary for classical CuAAC click chemistry. Cyanine5.5 DBCO is a cyclooctyne product containing Cyanine5.5 fluorescent dye. This fluorophore is used in bioimaging, biodistribution studies, and microscopy. Cyanine5.5 DBCO can be used to conjugate the fluorophore with various azides.

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      • Ref: BP-40694
        Sizes: 1 MG, 5 MG, 25 MG, 10 MG
        From: £137.00

        This product is a derivative of tetramethylrhodamine (TMR, TAMRA) containing a cyclooctyne moiety (dibenzocyclooctyne, DBCO). Pure 5-isomer. DBCO reacts quickly and efficiently with azides by simply mixing the components without the need for a copper catalyst (so-called sterically promoted cycloaddition reaction (SPAAC)). TAMRA DBCO can be used for the labeling of proteins, peptides, nucleic acids, and other molecules containing azide groups. TAMRA is often used as a FRET acceptor for FAM fluorophore. Can replace DyLight 549.

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      • Ref: BP-40695
        Sizes: 1 MG, 5 MG, 25 MG, 10 MG
        From: £137.00

        sulfo-Cyanine3 DBCO is a water-soluble fluorescent dye with cycloalkyne group for copper-free click chemistry. DBCO (dibenzocyclooctyne) is a cyclooctyne with very high reactivity towards azides, still possessing good stability.

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      • Ref: BP-40696
        Sizes: 1 MG, 5 MG, 25 MG, 10 MG
        From: £137.00

        Copper-free click chemistry reaction between strained cycloalkynes (cyclooctynes), and azides, is a very fast and robust reaction. It can be used for a fast labeling with fluorescent dyes. This reagent is a derivative of water soluble sulfo-Cyanine5 dye which emits in red channel. It is useful for the labeling of biomolecules in aqueous media.

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      • Ref: BP-40697
        Sizes: 25 MG, 100 MG, 50 MG
        From: £262.00

        Cyanine3.5 dimethyl is a non-sulfonated cyanine dye with good solubility in organic solvents and bright fluorescence in the yellow-orange spectrum range. The dye can be used as a non-reactive fluorophore for control experiments, calibration, and other technical applications.

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      • Ref: BP-40698
        Sizes: 25 MG, 100 MG, 50 MG
        From: £312.00

        Non-functionalized Cyanine7.5 dye derivative with an aliphatic side chain and good solubility in organic solvents. The dye can be used as a non-reactive fluorophore for control experiments and for calibration.

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