Cell-based Assays

PYROSTAR NEO+ IS A NEW ENDOTOXIN DETECTION REAGENT DEVELOPED BY RECOMBINANT TECHNOLOGY. COMBINE WITH TRADITIONAL LYSATE REAGENT AND RECOMBINANT 3 FACTORS (FACTOR C, FACTOR B, PROCLOTTING ENZYME) FROM LIMULUS POLYPHEMUS. IT IS A HIGH SENSITIVE COLORIMETRIC ASSAY SPECIFIC FOR ENDOTOXIN.

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI

THE LIMULUS COLOR KY SERIES INCLUDES BOTH A MULTI-TEST KIT AND A SINGLE-TEST KIT, EACH DESIGNED FOR TIME-BASED CHROMOGENIC ANALYSIS, USING A SYNTHETIC SUBSTRATE WHICH PRODUCES A YELLOW COLOR AND CAN SPECIFICALLY DETECT ENDOTOXIN WITH HIGH SENSITIVITY. PRODUCT FEATURES: • ENDOTOXIN-SPECIFIC LYSATE, AVOIDS FALSE POSITIVE RESULTS FROM GLUCANS • AVAILABLE IN MULTI-TESTS VIALS OR SINGLE-TEST VIALS • QUANTITATIVE KINETIC-CHROMOGENIC ASSAY (KCA) REAGENT • KCA ASSAYS CAN BE PERFORMED IN TUBE READER OR MICROPLATE READER • KCA QUANTITATIVE RANGE DETECTION LIMIT OF 0.0002 EU/ML (SINGLE-TYPE) AND 0.0005 EU/ML (MULTI-TYPE). • AVAILABLE WITH MATCHED CONTROL STANDARD ENDOTOXIN (CSE) • 100UL SAMPLE SIZE WHEN USED WITH TUBE READER; 50UL SAMPLE SIZE WHEN USED WITH MICROPLATE READER

THE LIMULUS COLOR KY SERIES INCLUDES BOTH A MULTI-TEST KIT AND A SINGLE-TEST KIT, EACH DESIGNED FOR TIME-BASED CHROMOGENIC ANALYSIS, USING A SYNTHETIC SUBSTRATE WHICH PRODUCES A YELLOW COLOR AND CAN SPECIFICALLY DETECT ENDOTOXIN WITH HIGH SENSITIVITY. PRODUCT FEATURES: • ENDOTOXIN-SPECIFIC LYSATE, AVOIDS FALSE POSITIVE RESULTS FROM GLUCANS • AVAILABLE IN MULTI-TESTS VIALS OR SINGLE-TEST VIALS • QUANTITATIVE KINETIC-CHROMOGENIC ASSAY (KCA) REAGENT • KCA ASSAYS CAN BE PERFORMED IN TUBE READER OR MICROPLATE READER • KCA QUANTITATIVE RANGE DETECTION LIMIT OF 0.0002 EU/ML (SINGLE-TYPE) AND 0.0005 EU/ML (MULTI-TYPE). • AVAILABLE WITH MATCHED CONTROL STANDARD ENDOTOXIN (CSE) • 100UL SAMPLE SIZE WHEN USED WITH TUBE READER; 50UL SAMPLE SIZE WHEN USED WITH MICROPLATE READER

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI

ENDOTOXIN EXTRACTING SOLUTION FOR LAL TEST TRADITIONALLY, WATER OR SALINE SOLUTION HAS BEEN USED TO EXTRACT ENDOTOXIN IN TESTS ON MEDICAL DEVICES AND EQUIPMENT; HOWEVER, THE EFFICACY OF THIS EXTRACTION METHOD HAS RECENTLY COME INTO QUESTION. IN ORDER TO PROVIDE OUR CUSTOMERS WITH A MORE RELIABLE METHOD FOR MEDICAL DEVICE TESTING, FUJIFILM WAKO HAS DEVELOPED AN ENDOTOXIN-FREE EXTRACTING SOLUTION CONTAINING HUMAN SERUM ALBUMIN (HSA) THAT IS CAPABLE OF EXTRACTING ENDOTOXINS WHICH CANNOT BE EXTRACTED IN WATER OR SALINE SOLUTION. PRODUCT FEATURES: • CAPABLE OF EXTRACTING ENDOTOXINS FROM SURFACES WHICH CANNOT BE EXTRACTED IN WATER OR SALINE • RECOMMENDED FOR USE IN ENDOTOXIN TESTING ON EQUIPMENT AND DEVICES WHICH MAY COME INTO CONTACT WITH FLUIDS CONTAINING BLOOD OR PROTEIN.

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI

PYROSTAR NEO IS A NEW ENDOTOXIN DETECTION REAGENT DEVELOPED BY RECOMBINANT TECHNOLOGY. COMBINE WITH TRADITIONAL LYSATE REAGENT AND RECOMBINANT 3 FACTORS (FACTOR C, FACTOR B, PROCLOTTING ENZYME) FROM LIMULUS POLYPHEMUS. IT IS A HIGH SENSITIVE COLORIMETRIC ASSAY SPECIFIC FOR ENDOTOXIN.