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    Results for Chemicals ( 21791 )

      • PROTAC BRD4 ligand-1

        Ref: T12551
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg
        From: €142.00

        PROTAC BRD4 ligand-1 (Legacy Tebubio ref. 282T12551). PROTAC BRD4 ligand-1, a component of Protac GNE-987, is a ligand for BRD4 and acts as an inhibitor of BET.

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      • PROTAC B-Raf degrader 1

        Ref: T12556
        Sizes: 5 mg, 10 mg
        Price Enquiry

        PROTAC B-Raf degrader 1 (Legacy Tebubio ref. 282T12556). PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.

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      • PROTAC BET degrader-2

        Ref: T12559
        Sizes: 5 mg, 25 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        PROTAC BET degrader-2 (Legacy Tebubio ref. 282T12559). PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins, with an IC50 of 9.6 nM.

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      • PROTAC BRD9 Degrader-1

        Ref: T12560
        Sizes: 5 mg, 10 mg
        Price Enquiry

        PROTAC BRD9 Degrader-1 (Legacy Tebubio ref. 282T12560). PROTAC BRD9 Degrader-1 is a leading PROTAC BRD9 chemical degrader with an IC50 of 13.5 nM.

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      • PROTAC α-synuclein degrader 5

        Ref: T79250
        Sizes: 5 mg
        From: €1,121.00

        PROTAC α-synuclein degrader 5 (Legacy Tebubio ref. 282T79250). PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].

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      • Soluble Epoxide Hydrolase PROTAC 1a

        Ref: T83857
        Sizes: 1 mg, 5 mg
        From: €653.00

        Soluble Epoxide Hydrolase PROTAC 1a (Legacy Tebubio ref. 282T83857). Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its hydrolase activity (IC50 = 0.8 nM) significantly more than its phosphatase activity (IC50 = >10,000 nM). This compound preferentially targets cytosolic sEH for lysosomal rather than proteasomal degradation. Furthermore, it mitigates thapsigargin-induced upregulation of phosphorylated inositol-requiring enzyme 1α (IRE1α) and X-box binding protein 1 (XBP1) splicing in HepG2 and 293T cells, thereby reducing endoplasmic reticulum stress.

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      • PROTAC BRAF-V600E degrader-2

        Ref: T8744
        Sizes: 5 mg
        From: €1,121.00

        PROTAC BRAF-V600E degrader-2 (Legacy Tebubio ref. 282T8744). PROTAC BRAF-V600E degrader-2 is a useful organic compound for research related to life sciences. The catalog number is T8744 and the CAS number is 2417296-82-1.

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      • PROTAC BRAF-V600E degrader-1

        Ref: T8745
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg
        From: €131.00

        PROTAC BRAF-V600E degrader-1 (Legacy Tebubio ref. 282T8745). PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.

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      • FKBP12 PROTAC RC32

        Ref: T13694
        Sizes: 1 mg
        From: €245.00

        FKBP12 PROTAC RC32 (Legacy Tebubio ref. 282T13694). FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.

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