Labelling

ATTO488-Charybdotoxin is a fluorescent version of Charybdotoxin. Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca2+ activated K+ channels KCa1.1 in nanomolar concentrations (IC50~ 3 nM). This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocks KCa3.1 (IC50 5 nM), Kv1.2 (IC50 14 nM), Kv1.3 (IC50 2.6 nM) and Kv1.6 (IC50 2 nM) channels. ATTO488: λex 500nm , λem 520nm

Amino-PEG46-Alcohol represents a bifunctional PEG linker with a terminal amino group that reacts with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc., and hydroxyl which reacts with a variety of functional groups. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.