Lipids & Polymers

dTAG-47 is a heterobifunctional compound designed to target the mutant FKBP12, which functions as a degradation tag when fused to a protein of interest. This unique structure facilitates targeted protein degradation, making it a valuable tool for investigating basal-like breast cancers. Its bifunctional nature enhances selectivity and efficacy in protein modulation studies.

FC-11 is a PROTAC that targets focal adhesion kinase (FAK) for degradation. It features a Cereblon ligand from Pomalidomide, a linker, and a FAK ligand, PF562271. This compound effectively degrades FAK in various cell types, making it a useful tool for studying FAK-related signaling pathways.

Multitube Magnetic Separator, 10 x 1.5 mL tubes. The ten inserts of the separator are designed to hold 1 - 2 mL centrifuge tubes.

Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].

Ald-CH2-PEG3-azide is a cleavable 3-unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Bis-PEG4-acid is a PEG PROTAC linker (PROteolysis TArgeting Chimera) used in targeted protein degradation applications.

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].

DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1].

Fmoc-NH-PEG8-CH2CH2COOH (Fmoc-N-amido-PEG8-acid) is a degradable ADC linker for the synthesis of ADC compounds.