Lipids

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2.GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested. Bulk discounts available please email echelon@echelon-inc.com for information.

BODIPY TMR PI(3 4 5)P3 (BODIPY TMR Phosphatidylinositol 3 4 5-trisphosphate) is a water soluble analog of PI(3 4 5)P3 (PIP3) labeled with the orange fluorophore Bodipy®-TMR at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2. Bulk discounts available please email echelon@echelon-inc.com for information. Powered by Bioz See more details on Bioz

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2.GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.Bulk discounts available please email echelon@echelon-inc.com for information.

Biotin Phosphatidylinositol 4 5-bisphosphate is a water soluble analog of PI(4 5)P2 (PIP2) labeled with biotin at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.Storage-20 °CPublications Powered by Bioz See more details on Bioz1) Rzepecki P. W. and G. D. Prestwich (2002). "Synthesis of hybrid lipid probes: derivatives of phosphatidylethanolamine-extended phosphatidylinositol 4 5-bisphosphate (Pea-PIP(2))." J Org Chem 67(16): 5454-60.2) Goksoy E. Y.-Q. Ma et al. (2008). "Structural Basis for the Autoinhibition of Ta

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested. Powered by Bioz See more details on BiozBulk discounts available please email echelon@echelon-inc.com for information.

BODIPY FL Phosphatidylinositol 4 5-bisphosphate is a water soluble analog of PI(4 5)P2 (PIP2) labeled with the green fluorophore Bodipy®-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.Bulk discounts available please email echelon@echelon-inc.com for information. Powered by Bioz See more details on Bioz

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.Bulk discounts available please email echelon@echelon-inc.com for information. Powered by Bioz See more details on Bioz

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513) BODIPY®-TMR (544/574) or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested. Powered by Bioz See more details on BiozBulk discounts available please email echelon@echelon-inc.com for information.