Enzymes

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.

Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.

Recombinant Human Urokinase-Type Plasminogen Activator is a serine protease, which specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Human Urokinase-Type Plasminogen Activator is initially synthesized as 431 amino acid precursor with a N-terminal signal peptide residues. The single chain molecule is processed into a disulfide-linked two-chain molecule. There exists two forms A chain, the long A chain contains an EGF-like domain that is responsible for binding of the uPA receptor. The B chain corresponds to the catalytic domain.

Recombinant human FGFR2C (Fibroblast Growth Factor Receptor 2C) protein corresponding to the extracellular domain, encompassing amino acids 22-377. This construct contains a C-terminal human IgG1 Fc domain, followed by an Avi-Tag™. This protein was affinity purified.

Recombinant human CERK (ceramide kinase), encompassing amino acids 1-537(end). This construct contains a C-terminal FLAG-tag and two mutations of interest (K298G and K303G). This protein was affinity purified.

Complex of recombinant human CDK9 (Cyclin-dependent kinase 9), full length, amino acids 2-372(end), and recombinant human CyclinK, full length, amino acids 2-354(end). The CDK9 construct contains an N-terminal GST tag followed by a PreScission protease cleavage site, while the CyclinK construct contains an N-terminal GST-tag followed by a thrombin cleavage site. The proteins were co-expressed and purified as a complex.

Human ANGPT2 full-length ORF (ADR83012.1, 1 a.a. - 496 a.a.) recombinant protein with GST tag at N-terminal.

Human FAR1 full-length ORF (AAH17377.1, 1 a.a. - 515 a.a.) recombinant protein with GST tag at N-terminal.