Chemicals & Small Molecules

Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity and calpain activity. Aclarubicin acts by forming a stable complex with DNA. It was originally identified as an antitumor agent. Cell permeable.

Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.

Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.

Dyphylline is a PDE inhibitor and a bronchodilator used to treat and/or prevent the symptoms of bronchial asthma, chronic bronchitis, and emphysema.

Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 µM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Pan-HDAC inhibitor; in vitro profiling of all conserved human HDACs of class I, II and IV showed that kaempferol inhibited all tested HDACs.

Antibiotic and antitumor agent. Covalently binds DNA forming intra- and interstrand crosslinks. Inhibits DNA synthesis.

Reagent optimized for use with BPS Bioscience's histone acetyltransferase (HAT) assay kits: GCN5 assay kit (#50091) or p300 assay kit (#50092).