Activators & Inhibitors

EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 400 pM. EPZ004777 selectively kills a variety of MLL-rearranged leukemia cells, including an MLL-AF4 leukemia cell line MV4-11 and an MLL-AF9 leukemia cell line MOLM13.

Sodium Phenylbutyrate is a transcriptional regulator that acts by altering chromatin structure via the modulation of HDAC activity.

Tankyrase Inhibitor 22 (TNKSi22) is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1 nM.

Tankyrase Inhibitor 49 (TNKSi49) is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1 nM.

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor . Tubacin does not inhibit HDAC6 histone deacetylase activity; instead, tubacin is specific for the tubulin deacetylase activity of HDAC6. It reversibly inhibits α-tubulin deacetylation in mammalian cells and increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity and calpain activity. Aclarubicin acts by forming a stable complex with DNA. It was originally identified as an antitumor agent. Cell permeable.

Aminophylline is a non-selective phosphodiesterase (PDE) inhibitor with an IC50 of 0.12 mM. Inhibition of PDE prevents the breakdown of secondary messenger molecules cAMP and cGMP, which play a vital role in signal transduction.

Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.